Version: 1.0.0 | Published: 24 Mar 2026 | Updated: 16 days ago
Summary
Description:
A National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre (BRC) dataset featuring serial NT-proBNP measurements from a diverse cohort of Intensive Care patients with sepsis, ARDS, and polytrauma.
Access Tier:
Controlled
Contact Point:
Health Theme:
Noncommunicable diseases – metabolic & cardiopulmonary
Health Category:
- Electronic Health Records (EHRs)
- Data from clinical trials, clinical studies & clinical investigations
Number of Unique Individuals:
552
Documentation
Associated Media:
Documentation:
A dataset of 552 patients who have been cared for on ICU.
Natriuretic peptides are special proteins produced by the heart, with the two key types being BNP and NT-proBNP. NT-proBNP is particularly useful in managing heart failure and assessing the risk of heart problems. This marker is not just for heart failure; studies have suggested that NT-proBNP levels during the acute phase of sepsis may be a useful indicator of higher risk of long-term impairments in physical function and muscle strength in sepsis survivors.
This dataset includes detailed demographic information, comorbidities and admission reasons and journeys for patients who have required an intensive care admission. The data includes serial physiological and blood test measurements reflecting the severity of the patient’s condition, imaging and other investigative results, treatments, and outcomes. This data is invaluable in identifying the clinical utility of NT-proBNP as a potential prognostic marker for future complications and mortality.
PIONEER geography: The West Midlands (WM) has a population of 6.2 million & includes a diverse ethnic & socio-economic mix.
EHR: UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & an expanded 250 ITU bed capacity during COVID. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health.”
Scope: Patients without chronic heart failure or acute heart failure diagnoses admitted to ICU with sepsis, acute respiratory failure (specifically ARDS) or polytrauma without severe head injury; with at least one measurement of NT-proBNP at any time from 3-months pre-ICU admission to 6 months post-ICU discharge
Longitudinal & individually linked, so that the preceding & subsequent health journey can be mapped & healthcare utilisation prior to & after admission understood. The dataset includes highly granular patient demographics & co-morbidities taken from ICD-10 & SNOMED-CT codes. Serial, structured data pertaining to acute care process (timings, hospital mortality, Length of stays, readmissions), Intensive care details, primary diagnosis, SOFA score & APACHE II scores, NT-proBNP results & outcomes.
Available supplementary data: Matched controls; ambulance, OMOP data, synthetic data.
Available supplementary support: PIONEER can also offer analytics, Model build, validation & refinement; A.I.; Data partner support for ETL (extract, transform & load) process, Clinical expertise, Patient & end-user access, Purchaser access, Regulatory requirements, Data-driven trials, “fast screen” services.
This research is supported by the National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre (BRC), specifically the Infections and Acute Care theme.
Coverage
Spatial
Spatial Coverage:
- United Kingdom
- England
- West Midlands
Temporal
Start Date:
14 February 2017
End Date:
06 October 2022
Frequency:
QUARTERLY
Date of Latest Release:
17 November 2023
Date of First Release:
08 October 2024
Temporal Aggregation:
1 - 10 Years
Provenance
Origin
Purpose:
Care
Collection Situation:
Secondary care - Accident and Emergency
Image Contrast:
Not stated
Method of Collection:
EPR
Access and Governance
Usage
Data Use Requirements:
Project specific restriction
Access
Jurisdiction:
England
Data Controller:
University Hospitals Birmingham NHS Foundation Trust
Delivery Lead Time:
1-2 months
Legal Basis:
General research use
Health Data Access Body:
This publication uses data from PIONEER, an ethically approved database and
analytical environment (East Midlands Derby Research Ethics 20/EM/0158)
Format and Standards
Language:
English
Format:
SQL
Conforms To:
LOCAL
Coding System:
- SNOMED CT
- ICD10
Data Distribution
Data Status:
Available
Distribution:
Trusted Research Environments (TRE) are built using Microsoft Azure services and
hosted in the UK to provide research teams a safe, secure and agile environment
which allows users to quickly analyse, interpret and form an enriched view of
primary care information through a range of integrated datasets. Health data
collated from multiple sources is ingested into a secure data lake which will
then allow subsets of data to be made available to research teams on approval of
a data request. Once approved a customer specific TRE is made available with a
standard set of leading analytical tools from Microsoft including Azure
Databricks, Azure Machine Learning, Azure SQL and Azure Synapse (for large-scale
data warehouses). Specific tools can be provided at an additional cost over the
standard platform data access charge and the PIONEER team will work with you to
determine your exact needs. Access to the TRE is managed using the latest
virtual desktop technology to provide a safe and secure end-user experience. By
utilising leading edge design PIONEER are able to create TREs rapidly to enable
us to service any customer requirement.,
www.pioneerdatahub.co.uk/data/data-services-costs/
Observations
Name
Population Type
Value
Description
Variable Measured
Unit Code
Observation Date
Number of Records
Minimum Typical Age
Maximum Typical Age
Persons
552
552 distinct patients admitted in ICU with sepsis, acute respiratory failure (specifically ARDS) or polytrauma without severe head injury
and with at least one measurement of NT-proBNP
Count
01 November 2022
552
16
100
Origin
Name:
Data Catalogue